ACOT1, ACOT2, and ACOT3 are involved in fatty acid metabolism and Cyp4a10, and Cyp4a14 are involved in the PPAR signaling pathway downregulated significantly after MSCs treatment in WD-induced NASH liver.

To identify the therapeutic role of hUC-MSCs cell therapy in WD-induced NASH, we established a NASH mouse model. We evaluated the therapeutic efficacy of human umbilical cord-derived Mesenchymal Stromal Cells (MSCs) in NASH mice and investigated the potential mechanism.

为明确人类脐带间充质基质细胞（human umbilical cord-derived Mesenchymal Stromal Cells，hUC-MSCs）疗法在西方饮食（Western Diet, WD）诱导的非酒精性脂肪性肝炎（Non-Alcoholic Steatohepatitis, NASH）中的治疗作用，本研究构建了NASH小鼠模型。本研究评估了人脐带来源间充质基质细胞（Mesenchymal Stromal Cells，简称MSCs）对NASH模型小鼠的治疗效果，并对其潜在作用机制进行了探究。