Table_1_Examining the intersection of cognitive and physical function measures: Results from the brain networks and mobility (B-NET) study.doc

Background and objectivesAlthough evidence exists that measures of mobility and cognition are correlated, it is not known to what extent they overlap, especially across various domains. This study aimed to investigate the intersection of 18 different objective cognitive and physical function measures from a sample of unimpaired adults aged 70 years and older.
Research design and methodsCanonical correlation analysis was utilized to explore the joint cross-sectional relationship between 13 cognitive and 6 physical function measures in the baseline visit of the Brain Networks and Mobility Function (B-NET) Study (n = 192).
ResultsMean age of participants was 76.4 years. Two synthetic functions were identified. Function 1 explained 26.3% of the shared variability between the cognition and physical function variables, whereas Function 2 explained 19.5%. Function 1 termed “cognitive and physical speed” related the expanded Short Physical Performance Battery (eSPPB), 400-m walk speed, and Dual Task gait speed measures of physical function to semantic fluency animals scores, Digit Symbol Coding (DSC), and Trail Making Test B. Function 2 termed “complex motor tasks and cognitive tasks” related the Force Plate Postural Sway Foam Task and Dual Task to the following cognitive variables: MoCA Adjusted Score, Verbal Fluency L words, Craft story immediate and delayed recall, and Trail Making Test B.
Discussion and implicationsWe identified groups of cognitive and physical functional abilities that were linked in cross-sectional analyses, which may suggest shared underlying neural network pathway(s) related to speed (Function 1) or complexity (Function 2).
Translational significanceWhether such neural processes decline before measurable functional losses or may be important targets for future interventions that aim to prevent disability also remains to be determined.

研究背景与目的：尽管已有研究证实行动能力与认知能力的测量指标存在相关性，但二者的重叠程度仍不明确，尤其是在不同功能域中。本研究旨在针对192名70岁及以上无认知受损成年人的样本，探究18项客观认知与躯体功能测量指标的交集关联。
研究设计与方法：本研究采用典型相关分析（Canonical Correlation Analysis），针对脑网络与躯体活动功能研究（Brain Networks and Mobility Function, B-NET）的基线评估访视数据（n=192），探究13项认知功能测量指标与6项躯体功能测量指标之间的联合横断面关联。
研究结果：本研究纳入的参与者平均年龄为76.4岁，共识别出2个综合功能维度。维度1可解释认知与躯体功能变量间26.3%的共享变异，维度2则可解释19.5%的共享变异。被命名为"认知与躯体速度"的维度1，将扩展版躯体功能表现量表（expanded Short Physical Performance Battery, eSPPB）、400米步行速度、双任务（Dual Task）步态速度等躯体功能测量指标，与动物语义流畅性得分、数字符号替换测验（Digit Symbol Coding, DSC）及连线测验B版（Trail Making Test B）的表现相关联。被命名为"复杂运动任务与认知任务"的维度2，将测力台姿势摇摆泡沫垫任务（Force Plate Postural Sway Foam Task）、双任务（Dual Task）等躯体任务，与蒙特利尔认知评估量表（Montreal Cognitive Assessment, MoCA）调整得分、L词汇口语流畅性测验、Craft故事即刻与延迟回忆测验及连线测验B版等认知变量相关联。
讨论与意义：本研究通过横断面分析识别出存在关联的认知与躯体功能能力集群，这提示可能存在与速度相关（维度1）或与复杂性相关（维度2）的共享潜在神经网络通路。
转化意义：这类神经过程是否会在可检测的功能损失之前出现衰退，或是可作为未来预防残疾的干预重要靶点，仍有待进一步研究确定。