Effect of fentanyl on the accumulation of doxorubicin and rhodamine123 in MCF-7 and MCF-7/adr cells.

The accumulation of doxorubicin (A, C) and rhodamine 123 (B, D) were measured by flow cytometric analysis. VRP = verapamil, as a positive control. Data from (E) (F) are shown as mean ± SD, n = 3.Columns, mean relative values of control group; bars, SD. *P < 0.05, **P< 0.01 versus control group.

通过流式细胞术分析，检测了阿霉素（doxorubicin，对应A、C组）与罗丹明123（rhodamine 123，对应B、D组）的细胞内蓄积水平。维拉帕米（verapamil，VRP）作为阳性对照。图E、F中的数据以平均值±标准差（mean ± SD）表示，每组样本量n=3。柱条代表对照组的平均相对值，误差棒代表标准差。与对照组相比，*P<0.05、**P<0.01具有统计学显著性差异。