Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

We performed T cell receptor (TCR) sequencing to study immune cell composition and (hyper-)expansion of circulating and joint-derived Tregs and non-Tregs in Juvenile Idiopathic Arthritis (JIA, N=9). We studied different joints affected at the same time, as well as over the course of relapsing remitting disease. Examination of circulating and joint derived (regulatory) T cell receptors from JIA patents

我们采用T细胞受体（T cell receptor, TCR）测序技术，旨在研究幼年特发性关节炎（Juvenile Idiopathic Arthritis, JIA，N=9）患者循环及关节来源的调节性T细胞（Tregs）与非调节性T细胞的免疫细胞构成及（过度）扩增情况。本研究既分析了疾病发作时同时受累的多组关节，也对复发缓解型疾病的病程进行了追踪。此外，我们还对JIA患者的循环及关节来源的（调节性）T细胞受体开展了检测分析。