measurement of levels of SOD,MDA,TFR1,SERUM IRON, and the immunohistochemistry of (HO1,GPX4) and the gene expression of SLC7A11 fold

The study examines the effects of liraglutide, a GLP-1 receptor agonist, on oxidative stress and ferroptosis-related indicators in obese rats. The rats were divided into five groups, and after a high-fat diet, liraglutide was administered subcutaneously for 28 days. Results showed that liraglutide reversed the reduction of antioxidant and ferroptosis-regulatory markers in obese rats, suggesting it may have cytoprotective effects and potentially treat obesity-associated oxidative stress and ferroptosis.本研究考察了利拉鲁肽（liraglutide）——一种GLP-1受体激动剂（GLP-1 receptor agonist）——对肥胖大鼠氧化应激（oxidative stress）及铁死亡（ferroptosis）相关指标的影响。实验将大鼠分为五组，经高脂饮食（high-fat diet）造模后，皮下注射利拉鲁肽，持续给药28天。结果显示，利拉鲁肽可逆转肥胖大鼠体内抗氧化标志物与铁死亡调控标志物的水平下降趋势，表明其具备细胞保护作用，或可用于治疗肥胖相关的氧化应激与铁死亡。