Monocyte Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Expression Correlates with cIMT in Mexican Hypertensive Patients

Abstract Background Arterial hypertension (HTA) represents a major risk factor for cardiovascular morbidity and mortality. It is not yet known which specific molecular mechanisms are associated with the development of essential hypertension. Objective In this study, we analyzed the association between LRP1 monocyte mRNA expression, LRP1 protein expression, and carotid intima media thickness (cIMT) of patients with essential hypertension. Methods The LRP1 monocyte mRNA expression and protein levels and cIMT were quantified in 200 Mexican subjects, 91 normotensive (NT) and 109 hypertensive (HT). Statistical significance was defined as p

背景：动脉高血压（Arterial hypertension, HTA）是心血管疾病发病率与死亡率的主要危险因素。目前尚不清楚哪些特异性分子机制与原发性高血压的发病相关。
研究目的：本研究分析了原发性高血压患者的LRP1单核细胞mRNA表达、LRP1蛋白表达与颈动脉内膜中层厚度（carotid intima media thickness, cIMT）之间的关联。
研究方法：本研究对200名墨西哥受试者开展检测，其中91名为血压正常者（normotensive, NT），109名为高血压患者（hypertensive, HT），对其LRP1单核细胞mRNA表达水平、蛋白水平及颈动脉内膜中层厚度进行了量化分析。
统计学显著性判定标准设定为p