Global transcriptional profiling of Staphylococcus aureus treated with magnolol

Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. magnolol has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with magnolol. Keywords: gene expression array-based, count Staphylococcus aureus cells were exposed for a certain time to magnolol at a certain concentration, 6 samples including 3 control samples are analyzed.

金黄色葡萄球菌（Staphylococcus aureus, S. aureus）是一类重要的人类及动物病原菌，其多重耐药菌株的传播日益广泛，针对该菌的治疗亟需新型抗菌制剂。厚朴酚（magnolol）对金黄色葡萄球菌具有强效抗菌活性。本研究采用Affymetrix金黄色葡萄球菌基因芯片（Affymetrix Staphylococcus aureus GeneChips™）阵列，探究经厚朴酚处理的金黄色葡萄球菌ATCC25923的全局转录谱。关键词：基于基因表达芯片的研究；将金黄色葡萄球菌细胞暴露于特定浓度的厚朴酚中并孵育特定时长；共分析6份样本，其中包含3份对照样本。