The rs10830963 SNP of the MTNR1B gene in the Czech cohort

Disruptions in biorhythms contribute to the development of type 2 diabetes mellitus. The MTNR1B gene encodes a receptor for melatonin, a hormone regulating biorhythms, and genetic studies suggest that variability in the MTNR1B gene is related to the development of T2DM, with the single nucleotide polymorphism rs10830963 showing the strongest association. Our aim was to compare the distribution of the genetic variant rs10830963 between persons differing in glucose tolerance (N=1206).

生物节律紊乱可促进2型糖尿病（type 2 diabetes mellitus, T2DM）的发生发展。MTNR1B基因编码褪黑素受体，褪黑素是一种调控生物节律的激素；既往遗传学研究表明，MTNR1B基因的变异与T2DM的发病相关，其中单核苷酸多态性（single nucleotide polymorphism, SNP）rs10830963的关联效应最强。本研究旨在比较不同糖耐量状态个体间遗传变异rs10830963的分布差异，总样本量为1206例。