Skin Biopsies and DNA Analysis in Patients Receiving Irinotecan or Gemcitabine For Advanced Solid Tumors

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This laboratory study is collecting skin biopsy specimens from patients receiving irinotecan or gemcitabine for advanced solid tumors and using them to study change in DNA due to this treatment.

研究背景：在实验室环境下对癌症患者的肿瘤组织样本开展研究，可帮助临床医师识别并深入了解与癌症相关的生物标志物（biomarker）。
研究目的：本实验室研究拟收集接受伊立替康（irinotecan）或吉西他滨（gemcitabine）治疗的晚期实体瘤患者的皮肤活检标本，并通过此类标本探究该治疗方案引发的DNA变化。