Gene expression alternations in the offspring adipose from chromium restriction diet dams

Maternal chromium restriction may disturb susceptibility in offspring. Adipose from maternal chromium diet has 85 up- and 109 down- regulated genes, compared to control. Especially, PPAR signaling pathway was affected. We performed microarray analyses of offspring adipose from chromium restriction dams and control diet dams at 32 week (n=3 per group).

母体铬限制可能对子代的易感性产生干扰。与对照组相比，母体铬限制饮食组的子代脂肪组织中存在85个上调基因与109个下调基因。其中，过氧化物酶体增殖物激活受体（PPAR）信号通路受到显著影响。本研究针对32周龄的子代脂肪组织开展了基因芯片分析，实验样本取自铬限制组母鼠与正常饮食对照组母鼠的子代，每组样本量为3（n=3 per group）。