Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (Targeted EM-Seq). Maternal Adiposity Alters Transcriptomic and Epigenomic Neurodevelopmental Landscapes in the Fetal Hippocampus (Targeted EM-Seq)

To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis Overall design: Comparative fetal baboon (0.9 term) hippocampal targeted EM-Seq analysis from dams with different adiposity and leptin levels

为探究母体肥胖与瘦素对胎儿大脑发育的影响，本研究于妊娠0.9胎龄时采集胎儿海马脑组织及脱氧核糖核酸（DNA），用于靶向EM-Seq测序分析。实验整体设计：针对肥胖程度与瘦素水平存在差异的孕母狒狒，开展其妊娠0.9胎龄胎儿海马组织的靶向EM-Seq测序比较分析。