Database FAR

Pancreatic surgery is one of the surgeries burdened with the highest mortality and morbidity rate. This is due both to the aggressive biological nature of the pathology affecting the organ and to the technical difficulties associated with surgery. A further aspect on which research is focusing is represented by inflammation related to oncological pathology. Inflammation plays an important role in tumor progression, and growing evidence has confirmed that the fibrinogen-to-albumin ratio (FAR) is an important prognostic factor for overall survival (OS) in malignant tumors.
Inflammatory markers had demonstrated also a role in the prediction of postoperative complication after pancreatic surgery.
We speculate that FAR, as an easily available, cost-effective, and non-invasive prognostic indicator for pancreatic cancer patients, could help to identify patients at increased risk of complications such as postoperative pancreatic fistula (POPF). We therefore retrospectively analyzed the data relating to 117 pancreatic resections relating direct and indirect markers of inflammation with the incidence of post-operative complications.

胰腺手术是死亡率与并发症发生率最高的外科手术类型之一。该现象既与累及胰腺的病变具有侵袭性生物学特性有关，也与手术本身存在的技术难点密切相关。当前研究关注的另一重要方向为肿瘤相关炎症。炎症在肿瘤进展过程中发挥关键作用，越来越多的研究证据证实，纤维蛋白原与白蛋白比值（fibrinogen-to-albumin ratio, FAR）是恶性肿瘤总生存期（overall survival, OS）的重要预后因素。
既往研究亦证实，炎症标志物可用于预测胰腺手术后的术后并发症发生风险。
本研究推测，作为一种易于获取、成本低廉且无创的胰腺癌患者预后评估指标，纤维蛋白原与白蛋白比值（FAR）可帮助识别术后胰瘘（postoperative pancreatic fistula, POPF）等并发症风险升高的患者。为此，我们对117例胰腺切除术患者的临床数据进行了回顾性分析，探讨直接与间接炎症标志物与术后并发症发生率之间的关联。