Phase Separation of Ligand-Activated Enhancers Licenses Cooperative Chromosomal Enhancer Assembly [ATAC-seq]. Homo sapiens

Detailed analysis of estrogen mediated enhancer landscape and chromosomal architectural changes specifically in human chromosome 21. Overall design: ATAC-seq experiments are designed to elucidate chromatin openness in human breast cancer cells (MCF7 WT and mutant) under basal or estrogen treated conditions.

针对人类21号染色体的雌激素介导增强子调控图谱及染色体构象变化的详细分析。实验设计概述：本研究采用ATAC-seq实验，旨在解析人类乳腺癌细胞（MCF7野生型与突变株）在基础培养条件或雌激素处理条件下的染色质开放状态。