A bibliometric and knowledge-map study on the treatment of hematological malignancies with CAR-T cells from 2012 to 2023

Recently, CAR-T cell therapy in hematological malignancies has received extensive attention. The objective of this study is to gain a comprehensive understanding of the current research status, development trends, research hotspots, and emerging topics pertaining to CAR-T cells in the treatment of hematological malignancies. Articles pertaining to CAR-T cell therapy for hematological malignancies from the years 2012 to 2023 were obtained and assessed from the Web of Science Core Collection (WoSCC). A bibliometric approach was employed to conduct a scientific, comprehensive, and objective quantitative analysis, as well as a visual analysis, of this particular research domain. A comprehensive analysis was conducted on a corpus of 3643 articles, which were collaboratively authored by 72 countries and various research institutions. CAR-T cell research in treating hematological malignancies shows an increasing trend each year. Notably, the study identified the countries and institutions displaying the highest level of activity, the journals with the most citations and output, as well as the authors who garnered the highest frequency of citations and co-citations. Furthermore, the analysis successfully identified the research hotspots and highlighted six emerging topics within this domain. This study conducted a comprehensive exploration and analysis of the research status, development trends, research hotspots, and emerging topics about CAR-T cells in the treatment of hematological malignancies from 2012 to 2023. The findings of this study will serve as a valuable reference and guide for researchers seeking to delve deeper into this field and determine the future direction of their research.

近年来，血液系统恶性肿瘤的嵌合抗原受体T细胞（CAR-T）疗法已受到学界广泛关注。本研究旨在全面厘清CAR-T细胞疗法在血液系统恶性肿瘤治疗领域的当前研究现状、发展趋势、研究热点及新兴议题。本研究从Web of Science核心合集（WoSCC）中获取了2012至2023年间与血液系统恶性肿瘤CAR-T细胞疗法相关的文献并进行纳入评估，随后采用文献计量学方法，对该研究领域开展科学、全面且客观的定量分析与可视化研究。本次分析共纳入72个国家及多家科研机构合作撰写的3643篇文献，并对其展开全面分析。研究结果显示，血液系统恶性肿瘤CAR-T细胞疗法相关研究呈逐年增长态势。值得注意的是，本研究明确了该领域活跃度最高的国家与科研机构、发文量与被引量均居前列的期刊，以及被引量和共被引频次最高的核心作者。此外，本分析还成功识别出该领域的研究热点，并提炼出六大新兴研究议题。本研究对2012至2023年间血液系统恶性肿瘤CAR-T细胞疗法的研究现状、发展趋势、研究热点及新兴议题进行了全面探索与系统分析，其结果可为致力于深入探索该领域并明确未来研究方向的科研人员提供极具价值的参考与指导。