Factor VIIA in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione

Protein Data Bank Japan2024-11-20 更新2026-03-21 收录

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Factor VIIA in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione Descriptor: (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... Authors: Wei, A. Deposit date: 2016-02-11 Release date: 2016-06-22 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. J.Med.Chem., 59, 2016

凝血因子VIIa（Factor VIIa）与抑制剂(2R,15R)-2-[(1-氨基异喹啉-6-基)氨基]-8-氟-7-羟基-4,15,17-三甲基-13-氧杂-4,11-二氮杂三环[14.2.2.1~6,10~]二十一碳-1(18),6(21),7,9,16,19-六烯-3,12-二酮（(2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione)）形成的复合物。数据集标识符：(2R,15R)-2-[(1-氨基异喹啉-6-基)氨基]-8-氟-7-羟基-4,15,17-三甲基-13-氧杂-4,11-二氮杂三环[14.2.2.1~6,10~]二十一碳-1(18),6(21),7,9,16,19-六烯-3,12-二酮、2-(N-吗啉代)乙磺酸、钙离子…… 作者：Wei, A. 提交日期：2016-02-11 发布日期：2016-06-22 最后修改日期：2024-11-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.06埃（Å）引用文献：《大环凝血因子VIIa抑制剂的阻转异构调控》（Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. J. Med. Chem., 59, 2016）

创建时间：

2016-02-11