Toxoplasma gondii-induced dysbiosis

Oral infection with Toxoplasma gondii results in a marked dysbiosis and the development of severe pathology in the distal small intestine that is dependent on CD4+ T cells and IFN-γ. This dysbiosis contributes to the development of ileal pathology and while immune-mediated Paneth cell loss promotes dysbiosis, the factors that support the bloom of bacterial pathobionts are still unclear. Using microbial community profiling, we investigated the mechanisms underlying T. gondii infection-induced dysbiosis .

口腔感染刚地弓形虫（Toxoplasma gondii）会引发显著的菌群失调，并在远端小肠诱发严重病变，该病变过程依赖CD4阳性T细胞与γ干扰素（IFN-γ）。此类菌群失调可促进回肠病变的发生；尽管免疫介导的潘氏细胞（Paneth cell）丢失会加剧菌群失调，但支撑条件致病共生菌（bacterial pathobionts）增殖的具体机制仍未明确。本研究通过微生物群落谱分析，探究了刚地弓形虫感染诱导菌群失调的潜在机制。