Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 16,17-EpDPE hydrolysis intermediate

Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 16,17-EpDPE hydrolysis intermediate Descriptor: (4Z,7Z,10Z,13Z,16R,17R,19Z)-16,17-dihydroxydocosa-4,7,10,13,19-pentaenoic acid, CFTR inhibitory factor Authors: Hvorecny, K.L, Madden, D.R. Deposit date: 2016-10-14 Release date: 2017-10-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure, 25, 2017

CFTR抑制因子Cif的E153Q突变体晶体结构，其结合有加合态16,17-环氧二十碳五烯酸（16,17-EpDPE）水解中间体。配体描述式：(4Z,7Z,10Z,13Z,16R,17R,19Z)-16,17-二羟基二十二碳-4,7,10,13,19-五烯酸。作者：Hvorecny, K.L.、Madden, D.R.。存放日期：2016-10-14。发布日期：2017-10-18。最后修改日期：2024-11-06。实验方法：X射线衍射（分辨率1.8 Å）。引用文献：《细菌毒力因子的活性位点柔性与底物特异性：环氧水解酶的晶体快照》，《Structure》，2017年，第25卷。