Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A

Protein Data Bank Japan2024-03-06 更新2026-03-21 收录

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Structure of Aspergillus fumigatus trehalose-6-phosphate synthase B in complex with UDP and validoxylamine A Descriptor: (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE Authors: Miao, Y, Brennan, R.G. Deposit date: 2016-01-28 Release date: 2017-05-03 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.467 Å) Cite: Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design. MBio, 8, 2017

烟曲霉（Aspergillus fumigatus）海藻糖-6-磷酸合酶B与尿苷二磷酸（UDP）及有效氧胺A复合物的结构 Descriptor: (1S,2S,3R,6S)-4-(羟甲基)-6-{[(1S,2S,3S,4R,5R)-2,3,4-三羟基-5-(羟甲基)环己基]氨基}环己-4-烯-1,2,3-三醇 α,α-海藻糖-磷酸合酶（UDP生成型），尿苷-5'-二磷酸（Uridine-5'-Diphosphate）作者：Miao Y、Brennan R.G. 提交日期：2016年1月28日发布日期：2017年5月3日最后修改日期：2024年3月6日实验方法：X射线衍射（2.467埃）引用文献：《病原真菌海藻糖-6-磷酸合酶的结构与体内研究为其催化机制、生物学必要性及新型抗真菌药物开发潜力提供新见解》，MBio，8卷，2017年

创建时间：

2016-01-28