Multi-ancestry genetic analysis of gene regulation in coronary artery prioritizes disease risk loci

All files contain results generated in coronary artery tissue from 138 American adults. Scripts accompanying some of these data in downstream analyses can be viewed on our Github, which also contains a link to the current version of our accompanying manuscript: https://github.com/MillerLab-CPHG/CAD_QTL Full summary statistics for eQTL associations using mixQTL (https://github.com/hakyimlab/mixqtl/wiki) by chromosome are located in UVA_coronary_mixQTL_sumstats_by_chromosome.zip Full summary statistics for nominal pass for all genes identified as significant in the permutation pass using QTLtools (https://qtltools.github.io/qtltools/) adjusting for local ancestry by gene by chromosome are located in Local_ancestry_UVA_coronary_QTLtools_nominal_sumstats.zip Full summary statistics for sQTL associations with splice junctions using QTLtools by gene are located in sQTL_results_UVA_coronary_full_sumstats.zip本数据集所有文件均包含来自138名美国成年人的冠状动脉组织的分析结果。部分配套数据的下游分析脚本可在我们的GitHub仓库查看，该仓库同时提供了配套论文当前版本的链接：https://github.com/MillerLab-CPHG/CAD_QTL。基于mixQTL工具（官方文档链接：https://github.com/hakyimlab/mixqtl/wiki）、按染色体划分的表达数量性状位点（expression Quantitative Trait Locus, eQTL）关联分析全汇总统计量，存储于UVA_coronary_mixQTL_sumstats_by_chromosome.zip压缩包中。针对通过置换检验阶段鉴定出的显著基因，使用QTLtools工具（官方文档链接：https://qtltools.github.io/qtltools/）并按基因、染色体划分、校正本地血统影响的名义检验阶段全汇总统计量，存储于Local_ancestry_UVA_coronary_QTLtools_nominal_sumstats.zip压缩包中。基于QTLtools工具、按基因划分的针对剪接位点的剪接数量性状位点（splicing Quantitative Trait Locus, sQTL）关联分析全汇总统计量，存储于sQTL_results_UVA_coronary_full_sumstats.zip压缩包中。