Development of gene expression signatures for ANP in HUVEC

Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC was measured at 0, 1 and 6 hours. Four independent experiments were performed at each time (0, 1 or 6 hours) for each experiment.

心房钠尿肽（Atrial Natriuretic Peptide，ANP）处理后人脐静脉内皮细胞（Human Umbilical Vein Endothelial Cells，HUVEC）的相关分析。ANP是一种心脏激素，可与鸟苷酸环化酶A（guanylate cyclase-A，GC-A）受体结合，在心血管稳态调控机制中发挥核心作用。本研究结果可为解析ANP在血管内皮细胞中的分子作用机制提供参考。研究人员分别在0、1和6小时三个时间点检测了ANP诱导的HUVEC基因表达情况；针对每个时间点（0、1或6小时），均开展四次独立实验。