Genome wide methylation analysis of breast cancer epithelia, adjacent normal epithelia, breast cancer cell lines, and blood DNA from healthy individuals. Homo sapiens

To define methylation markers of breast cancer for circulating tumor DNA, we compare the methylation characteristics of breast cancer and blood DNA of healthy individuals. Overall design: Bisulphite converted DNA from the 119 samples were hybridised to the Illumina Infinium HumanMethylation450 BeadChip为了鉴定循环肿瘤DNA（circulating tumor DNA）相关的乳腺癌甲基化标志物，本研究对比了乳腺癌样本与健康个体血液DNA的甲基化特征。整体实验设计：将119份样本经亚硫酸氢盐转化得到的DNA，与Illumina Infinium HumanMethylation450 BeadChip芯片进行杂交。