Cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the cryo-EM structure of the CRAC channel Orai in an open conformation; H206A gain-of-function mutation in complex with an antibody. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules in the deposit, as well as entry history and funding information. Data is provided for download as FASTA sequence format, the Protein Data Bases own PDB format, crystallographic information file (.cif), XML, the EM map, as well as the full validation file in either PDF or XML formats. Additionally, the PDB provides embedded visualization software to display a 3D view of the protein: PDB's Mol* viewer, NGL viewer, and JSmol. PDB provides protein family and gene product annotations, additional details about the experiment parameters, a Protein Feature Viewer (in the Sequence tab) which displays all available features and alignments of known polymer instances, and a genome view which provides graphical summaries of the correspondences between PDB Entity sequences and genomes.

本存档收录于结构生物信息学研究联合实验室（Research Collaboratory for Structural Bioinformatics）蛋白质数据库（PDB）中，包含通过冷冻电子显微镜技术获得的CRAC通道Orai在开放构象下的冷冻电镜结构数据；以及与抗体结合的H206A功能获得性突变复合物。该条目的主要摘要展示包括实验方法、验证、存档中的大分子和小分子信息，以及存档历史和资助信息。数据以FASTA序列格式、蛋白质数据库自有的PDB格式、晶体学信息文件（.cif）、XML、电子显微镜图以及PDF或XML格式的完整验证文件提供下载。此外，PDB还提供了内置的可视化软件以展示蛋白质的3D视图：PDB的Mol*查看器、NGL查看器和JSmol。PDB提供蛋白质家族和基因产物注释，关于实验参数的详细信息，蛋白质特征查看器（位于序列标签页）可展示所有已知聚合物实例的特征和比对，以及基因组视图，该视图提供了PDB实体序列与基因组之间对应关系的图形摘要。