Random-coefficients linear mixed model to analyze the influence of mtDNA haplogroups on change in cartilage volume (upper) and thickness (lower) over time in 381 knee OA patients in the progression subcohort of the OAI.

BMI: body mass index; B: regression coefficient; SE: standard error; (†) the coefficient of each haplogroup represents the mean difference between a particular haplogroup and the reference haplogroup H at baseline; (¥) shows the interaction between the mtDNA haplogroups and the loss rate of cartilage volume and thickness over time; (#) linear mixed-effects random-intercept and random-slope repeated measures analysis adjusting for gender, age and BMI at baseline and considering the most common mtDNA haplogroup, H, as the reference group; (*): indicates statistical significance at p≤0.05.
Random-coefficients linear mixed model to analyze the influence of mtDNA haplogroups on change in cartilage volume (upper) and thickness (lower) over time in 381 knee OA patients in the progression subcohort of the OAI.

BMI：身体质量指数（body mass index）；B：回归系数（regression coefficient）；SE：标准误（standard error）；(†) 各单倍群的系数代表特定单倍群与参照单倍群H在基线时的均值差异；(¥) 表示线粒体DNA（mtDNA）单倍群与软骨体积和厚度随时间的丢失速率之间存在交互作用；(#) 该分析为线性混合效应随机截距-随机斜率重复测量分析，校正了基线时的性别、年龄与身体质量指数，并以最常见的线粒体DNA单倍群H作为参照组；(*) 表示当p≤0.05时具有统计学显著性。
本研究采用随机系数线性混合模型，旨在分析OAI进展亚队列中381例膝骨关节炎（knee OA）患者的线粒体DNA单倍群对软骨体积（上图）与厚度（下图）随时间变化的影响。