ETIOPATHOGENIC, EPIDEMIOLOGIC AND CLINICAL-THERAPEUTIC COMPARISON OF NON-HODGKIN’S LYMPHOMA AND KAPOSI’S SARCOMA

ABSTRACT Background: Non-Hodgkin’s lymphomas (NHL) are primary neoplasms derived from lymphocytes, and Kaposi’s sarcoma (SK) is a multicentric disease of viral etiology and is associated with HIV. Aim: To study the etiopathogenesis and clinical characteristics of NHL and KS, describing their mutual factors. Methods: This retrospective investigation was performed on 101 medical charts. The patients were studied according to their age, gender, and HIV-positivity, following the PRISMA guidelines. The characteristics of the tumors and comorbidities were analyzed according to their age and lymphatic metastasis. Results: The mean age of the patients ranged between 15-87 years for NHL and between 25-54 for KS, but the age of patients with NHL associated with HIV did not surpass 34 years. The ratio male: female was 1,8:1 for NHL, but only men presented KS. HIV-positivity was found in five patients with NHL and in 14 with KS. The stages of NHL were: I (21%), II (18,4%), III (26,3%), and IV (34,2%), but KS were found only at III (40%) and IV (60%) stages. The lymphatic metastases were positive in 62 patients NHL and in four with KS. HIV-positivity occurred in 60% of patients with NHL and in 50% with KS. Conclusion: The HIV seropositivity was revealed for most of patients during the NHL and SK propaedeutic and none of them present clinical manifestations of AIDS. NHL associated with HIV was found only in young patients. NHL and KS patients have similar epidemiological, clinical, and therapeutic characteristics.

摘要
背景：非霍奇金淋巴瘤（Non-Hodgkin’s lymphomas, NHL）是起源于淋巴细胞的原发性肿瘤，卡波西肉瘤（Kaposi’s sarcoma, SK）是一种病毒源性多中心疾病，且与人类免疫缺陷病毒（HIV）感染相关。
目的：旨在探究NHL与KS的发病机制及临床特征，阐明二者的共通影响因素。
方法：本回顾性研究纳入101份病历资料，遵循PRISMA指南（PRISMA guidelines），按患者年龄、性别及HIV感染状态开展分析，并根据年龄与淋巴转移情况对肿瘤特征及合并症进行研究。
结果：NHL患者的平均年龄区间为15~87岁，KS患者为25~54岁，但合并HIV感染的NHL患者年龄均未超过34岁。NHL患者的男女比例为1.8:1，而KS患者仅为男性。5例NHL患者及14例KS患者HIV检测呈阳性。NHL的临床分期为：I期（21%）、II期（18.4%）、III期（26.3%）及IV期（34.2%），而KS仅见于III期（40%）与IV期（60%）患者。62例NHL患者存在淋巴转移阳性，KS患者中仅4例出现淋巴转移阳性。HIV感染率在NHL患者中为60%，KS患者中为50%。
结论：多数接受NHL与SK诊断前期筛查的患者HIV血清学呈阳性，且均未出现艾滋病（AIDS）的临床表现。合并HIV感染的NHL患者仅见于年轻群体。NHL与KS患者在流行病学、临床及治疗特征上具有相似性。