Utilizing of quantitative proteomics to identify species-specific protein therapeutic target for treatment of leishmaniasis.

Identification of common Leishmania antigen proteins is important for practical purposes ranging from diagnostic to the development of a vaccine for the prevention of leishmaniasis. Moreover, we need to establish the potential drug targets that interrupt the replication and transmission of the pathogen to promote drug discovery. Therefore, the objective of this work was to provide the public proteome database which would be useful for the establishment of novel protein antigenicity for therapeutic purposes. This information would introduce the alternative protein targets for Leishmaniasis, allowing the development of therapeutic strategies for the disease.

鉴定常见的利什曼原虫（Leishmania）抗原蛋白，在从诊断到开发利什曼病（leishmaniasis）预防疫苗的各类实际应用中均具有重要意义。此外，亟需确定可阻断该病原体复制与传播的潜在药物靶点，以推动抗利什曼病药物的研发进程。因此，本研究旨在构建面向公众开放的蛋白质组数据库（proteome database），为开发针对利什曼病的新型蛋白抗原疗法提供支撑。该数据库所涵盖的信息将为利什曼病提供替代性蛋白靶点，助力相关疾病治疗策略的开发工作。