One-Pot Synthesis of Diaryl 1,2-Diketones via Zn-Mediated Reductive Coupling

A reductive coupling reaction was established for the synthesis of diaryl 1,2-dicarbonyl compounds from aryl methyl ketones in good yields. The mechanistic study showed the reaction undergoes C(CO)–C(sp3) bond cleavage, with the reductive coupling reaction occurring through an electron transfer process. Notably, the reaction not only is simple to operate but also has mild reaction conditions and a wide range of applicable substrates.本研究建立了一种还原偶联反应，可从芳基甲基酮出发合成二芳基1,2-二羰基化合物，且产物收率良好。机理研究表明，该反应经历了C(CO)–C(sp³)键的断裂过程，还原偶联步骤通过电子转移机制进行。值得注意的是，该反应不仅操作简便，反应条件温和，且适用底物范围广泛。