Dataset from Open-Label, Single-Sequence Study to Evaluate the Effects of Darunavir/Ritonavir and/or Etravirine on the Pharmacokinetics of GSK3640254 and the Effects of GSK3640254 on the Pharmacokinetics of Darunavir/Ritonavir and/or Etravirine in Heathy Adults

This is an open-label, single-sequence, multiple-dose, 3 cohort study to investigate the effects of DRV/RTV and/or ETR on the pharmacokinetics (PK) of GSK3640254 and the effects of GSK3640254 on the PK of DRV/RTV and/or ETR. This study will aid in understanding these interactions and resulting changes in exposure (if any) when given in combination with GSK3640254.

本研究为开放标签、单序列、多剂量三队列临床试验，旨在探究DRV/RTV及/或ETR对GSK3640254药代动力学（pharmacokinetics, PK）的影响，以及GSK3640254对DRV/RTV及/或ETR药代动力学的影响。本研究将助力阐明此类药物相互作用，以及联合GSK3640254给药时所产生的暴露量变化（若存在）。