Characterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling.

Data from ProteomeXchange, PXD ID: PXD000471. Experiment: 101207_EA_E, file: 101215_EA_E13.mzml. Published as part of . From the Abstract: {{i}} In addition to forming macrophages and dendritic cells, monocytes in adult peripheral blood retain the ability to develop into osteoclasts, mature bone-resorbing cells. The extensive morphological and functional transformation that occurs during osteoclast differentiation requires substantial reprogramming of gene and protein expression. Here we employ -omic scale technologies to examine in detail the molecular changes at discrete developmental stages in this process (precursor cells, intermediate osteoclasts and multinuclear osteoclasts), quantitatively comparing their transcriptomes and proteomes ... {{/i}}

本数据集数据来源于蛋白质组交换数据库（ProteomeXchange），其PXD编号为PXD000471。对应实验为101207_EA_E，所用数据文件为101215_EA_E13.mzml。该数据集作为[原文此处未明确具体出版物名称]的一部分公开发表。其摘要如下：{{i}}成年外周血中的单核细胞除可分化为巨噬细胞与树突状细胞外，还具备分化为破骨细胞——一种成熟的骨吸收细胞——的能力。破骨细胞分化过程中发生的广泛形态与功能重塑，需要对基因与蛋白质表达进行大规模重编程。本研究采用组学规模技术，详细解析该进程中不同发育阶段（前体细胞、中间型破骨细胞以及多核破骨细胞）的分子变化，并对其转录组与蛋白质组进行定量比较...{{/i}}