Ir(III)-Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of <i>N</i>‑Methoxy­isoquinoline­diones and <i>N</i>‑Methoxy­isoquinolinones

A mild and efficient Ir­(III)-catalyzed C–H carbenoid functionalization strategy has been developed to access N-methoxyiso­quinolinediones and N-methoxy­isoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any additional oxidants or a base.本研究开发了一种温和高效的三价铱（Ir(III)）催化C-H卡宾体官能化策略，可用于制备N-甲氧基异喹啉二酮与N-甲氧基异喹啉酮。该反应可在室温条件下高效进行，产率优异，底物适用范围广泛，且无需额外添加氧化剂或碱。