Comparative study of peritoneal adhesions after intraperitoneal implantation in rats of meshes of polypropylene versus polypropylene/polyglecaprone versus polyester/porcine collagen

Abstract Purpose To Compare the extent and intensity of adhesions formed between the intra-abdominal organs and the intraperitoneal implants of polypropylene mesh versus polypropylene/polyglecaprone versus polyester/porcine collagen used for correction of abdominal wall defect in rats. Methods After the defect in the abdominal wall, thirty Wistar rats were placed in three groups (ten animals each) for intraperitoneal mesh implant: polypropylene group, polypropylene/polyglecaprone group, and polyester/porcine collagen group. The macroscopic evaluation of the extent and intensity of adhesions was performed 21 days after the implant. Results The polypropylene group had a higher statistically significant impairment due to visceral adhesions (p value = 0.002) and a higher degree of intense adherence in relation to polypropylene/polyglecaprone and polyester/porcine collagen groups (p value<0.001). The polyester/porcine collagen group showed more intense adhesions than the polypropylene/polyglecaprone group (p value=0.035). Conclusions The intraperitoneal implantation of polypropylene meshes to correct defects of the abdominal wall caused the appearance of extensive and firm adhesions to intra-abdominal structures. The use of polypropylene/polyglecaprone or polyester/porcine collagen tissue-separating meshes reduces the number and degree of adhesions formed.

摘要
目的 比较用于大鼠腹壁缺损修补的三种腹腔内植入材料——聚丙烯网片（polypropylene mesh）、聚丙烯/聚卡普隆网片（polypropylene/polyglecaprone mesh）与聚酯/猪胶原蛋白网片（polyester/porcine collagen mesh）所形成粘连的范围与强度。
方法 建立大鼠腹壁缺损模型后，将30只Wistar大鼠分为3组（每组10只）实施腹腔内网片植入：聚丙烯组、聚丙烯/聚卡普隆组及聚酯/猪胶原蛋白组。于植入后21天对粘连的范围与强度进行宏观评估。
结果 聚丙烯组因内脏粘连引发的损伤具有统计学显著性差异（P=0.002），且其重度粘连程度高于聚丙烯/聚卡普隆组与聚酯/猪胶原蛋白组（P<0.001）；聚酯/猪胶原蛋白组的粘连程度较聚丙烯/聚卡普隆组更为严重（P=0.035）。
结论 采用聚丙烯网片行腹腔内植入修补腹壁缺损，会导致腹腔内脏器出现广泛且牢固的粘连；使用聚丙烯/聚卡普隆或聚酯/猪胶原蛋白隔离型网片，可减少粘连的发生数量并降低其严重程度。