HipSci___Whole_Exome_sequencing___healthy_volunteers

The HipSci project brings together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies. In this sub-study we perform whole exome sequencing using Agilent whole exome pulldown method on iPS cells generated from skin biopsies from healthy volunteers.

HipSci项目汇聚了基因组学、蛋白质组学、细胞生物学与临床遗传学等多个领域的研究力量，旨在构建英国国家诱导多能干细胞（iPS cell）资源库，并依托该资源开展细胞遗传学研究。在本次子研究中，我们采用安捷伦（Agilent）全外显子下拉法，对从健康志愿者皮肤活检样本中分离得到的诱导多能干细胞开展全外显子组测序。