Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression [RNA-Seq]. Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression [RNA-Seq]

our study establishes FOXA1 as an important regulator of lineage plasticity mediated in part by TGF-β signaling and supports a novel therapeutic strategy to control lineage switching and potentially extend clinical response to antiandrogen therapies. Overall design: RNA-seq examination of LNCaP cells with control and FOXA1 knockdown

本研究确立了叉头框A1（FOXA1）作为谱系可塑性（lineage plasticity）的重要调控因子，其调控作用部分由转化生长因子β（TGF-β）信号通路介导，并支持了一种可调控谱系转换、且有望延长抗雄激素治疗临床应答的全新治疗策略。
实验整体设计：对对照组与FOXA1敲低的LNCaP细胞开展RNA测序（RNA-seq）分析。