Exploring Transmission Dynamics in Epidemiologically linked pulmonary tuberculosis cases and household contacts: a WGS-based investigation

Whole-genome sequencing of Mycobacterium tuberculosis isolates from bacteriologically confirmed pulmonary tuberculosis patients and their household contacts in Central Ethiopia was performed to characterize drug resistance mutations and lineages. Illumina NextSeq 500/550 was used for sequencing.PI: Getachew Seid AbegazAffiliation: Addis Ababa University, Ethiopian Public Health Institute.

本研究对埃塞俄比亚中部经细菌学确诊的肺结核患者及其家庭接触者的结核分枝杆菌（Mycobacterium tuberculosis）分离株开展全基因组测序，以解析其耐药突变与进化谱系。测序采用Illumina NextSeq 500/550平台完成。项目首席研究员（PI）：格塔丘·赛义德·阿贝加兹；依托单位：亚的斯亚贝巴大学、埃塞俄比亚公共卫生研究所。