Enantioselective Bromoaminocyclization of Allyl <i>N</i>‑Tosylcarbamates Catalyzed by a Chiral Phosphine–Sc(OTf)₃ Complex

An effective enantioselective bromoaminocyclization of allyl N-tosylcarbamates catalyzed by a chiral phosphine–Sc­(OTf)3 complex is described. A wide variety of optically active oxazolidinone derivatives containing various functional groups can be obtained with high enantioselectivities.本研究报道了一种由手性膦-三氟甲磺酸钪(Sc(OTf)3)配合物催化的烯丙基N-对甲苯磺酰基氨基甲酸酯的高效对映选择性溴代氨基环化反应。该方法可制备得到一系列含不同官能团的光学活性恶唑烷酮衍生物，且产物均具有较高的对映选择性。