Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)

Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide) Descriptor: Bifunctional ligase/repressor BirA, N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide Authors: De la Mora-Rey, T, Finzel, B.C. Deposit date: 2015-01-24 Release date: 2015-09-02 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.45000836498 Å) Cite: Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J.Med.Chem., 58, 2015

结核分枝杆菌（Mycobacterium tuberculosis）生物素连接酶与双底物抑制剂36（N-({[(1R,3S)-3-(6-氨基-9H-嘌呤-9-基)环戊基]甲基}氨磺酰基)-5-[(3aS,4S,6aR)-2-氧代六氢-1H-噻吩并[3,4-d]咪唑-4-基]戊酰胺）的复合物。描述：双功能连接酶/阻遏蛋白BirA，N-({[(1R,3S)-3-(6-氨基-9H-嘌呤-9-基)环戊基]甲基}氨磺酰基)-5-[(3aS,4S,6aR)-2-氧代六氢-1H-噻吩并[3,4-d]咪唑-4-基]戊酰胺。作者：De la Mora-Rey, T.、Finzel, B.C.。存档日期：2015-01-24；发布日期：2015-09-02；最后修改日期：2023-09-27。实验方法：X射线衍射（分辨率1.45000839 Å）。引用文献：《以核苷类双底物腺苷化抑制剂靶向结核分枝杆菌生物素蛋白连接酶（Mycobacterium tuberculosis Biotin Protein Ligase, MtBPL）》，《药物化学杂志》（J.Med.Chem.），第58卷，2015年。