Tailored Bisacylphosphane Oxides for Precise Induction of Oxidative Stress-Mediated Cell Death in Biological Systems

Precise cell elimination within intricate cellular populations is hampered by issues arising from the multifaceted biological properties of cells and the expansive reactivity of chemical agents. Current chemical platforms are often limited by their complexity, toxicity, and poor physical/chemical properties. Here, we report on the synthesis of a structurally versatile library of chemically tunable bisacylphosphane oxides (BAPOs), which harnesses the spatiotemporal precision of light delivery, thereby establishing a universal strategy for on-demand, precise cellular ablation in vitro and in vivo.

在复杂的细胞群体中实现精准细胞清除，往往会受到细胞多维度生物学特性与化学试剂广谱反应性所引发的各类问题的阻碍。当前的化学清除平台通常受限于其自身的复杂性、毒性以及欠佳的物理与化学性能。本研究报道了一种结构多样、可化学调控的双酰基膦氧化物（bisacylphosphane oxides, BAPOs）文库的合成方法，该文库借助光递送的时空精准性，由此构建出一种可按需在体外及体内实现精准细胞消融的通用策略。