Altered gut microbiome composition by appendectomy contributes to colorectal cancer

Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk through causing gut microbial dysbiosis. We confirmed that appendectomy promoted colorectal tumorigenesis in mice by causing gut microbial dysbiosis and impaired intestinal barrier function. And we further detected the difference of gene expression in tumor tissue of post-appendectomy mice (n=3) compared to the control mice (n=3) by RNA sequencing.

阑尾切除术（Appendectomy）可影响患者肠道微生物群的稳态。本研究旨在明确阑尾切除术通过诱导肠道微生物群失调，在结直肠癌（colorectal cancer, CRC）发病风险中的作用。本研究证实，阑尾切除术可通过引发肠道微生物群失调并损伤肠道屏障功能，促进小鼠结直肠肿瘤发生。本研究进一步通过RNA测序（RNA sequencing），对比了阑尾切除术后小鼠（n=3）与对照小鼠（n=3）的肿瘤组织基因表达差异。