A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy

This pilot study will determine changes over time in tumor volume/motion & patient anatomy, as well as dose distributions to normal organs. The study will inform medical decision-making about need for (and timing of) re-calibration of radiation dosimetry plans. Weekly CT and/or serial MR scans will be employed for those patients receiving 7-8 wks of radiation therapy. The study will enroll 30 patients in each stratum: Non small cell lung cancer (NSCLC), Head & Neck, gastrointestinal (GI) and Gynecologic tumor.

本先导性研究旨在探究肿瘤体积/运动、患者解剖结构以及正常器官受照剂量分布随时间的变化情况。本研究将为放射剂量计划的重新校准需求及时机的临床决策提供依据。对于接受7至8周放射治疗的患者，本研究将采用每周一次的计算机断层扫描（CT）及/或系列磁共振成像（MR）扫描。本研究将在四个研究分层各纳入30例患者，分别为非小细胞肺癌（NSCLC）、头颈部肿瘤、胃肠道（GI）肿瘤及妇科肿瘤。