Global modulation of signaling pathways by SARM RAD140 in AR/ER+ breast cancer xenografts

These data demonstrates the regulation of AR and ER pathways by the SARM RAD140 and suggested a unique mechanism of action of RAD140 via the AR-mediated transcription repression. Overall design: HBCx-22 PDX were treated with RAD140 or vehicle and snap frozen tumor samples were subjected to RNA-seq analysis at the end of the study

本数据集揭示了SARM RAD140对雄激素受体（Androgen Receptor, AR）与雌激素受体（Estrogen Receptor, ER）通路的调控作用，并提示RAD140通过AR介导的转录抑制发挥独特的作用机制。实验设计概述：将HBCx-22人源肿瘤异种移植模型（Patient-Derived Xenograft, PDX）经RAD140或赋形剂处理后，在实验结束时获取快速冷冻的肿瘤样本并开展RNA-seq分析。