Data_Sheet_1_Effects of a polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study.docx

BackgroundPolyphenols are naturally occurring organic compounds found in plants. Research suggests that their intake reduces the risk of cognitive decline and related dementias. Grapes and blueberries are polyphenol-rich foods that have attracted attention for their potential cognitive-enhancing effects.
PurposeExamine the effects of supplementation with a standardized and patented polyphenol-rich grape and blueberry extract (Memophenol™) on cognitive function in older adults with mild cognitive impairment.
Study designTwo-arm, 6 month, parallel-group, randomized, double-blind, placebo-controlled trial.
MethodsOne hundred and forty-three volunteers aged 60 to 80 years with mild cognitive impairment were supplemented with either 150 mg of Memophenol™, twice daily or a placebo. Outcome measures included computer-based cognitive tasks, the Behavior Rating Inventory of Executive Function (BRIEF-A), the Cognitive Failures Questionnaire, and the CASP-19.
ResultsCompared to the placebo, Memophenol™ supplementation was associated with greater improvements in the speed of information processing (p = 0.020), visuospatial learning (p = 0.012), and the BRIEF-A global score (p = 0.046). However, there were no other statistically significant between-group differences in the performance of other assessed cognitive tests or self-report questionnaires. Memophenol™ supplementation was well-tolerated with no reports of significant adverse reactions.
ConclusionThe promising results from this trial suggest that 6-months of supplementation with Memophenol™ may improve aspects of cognitive function in adults with mild cognitive impairment. Further research will be important to expand on the current findings and identify the potential mechanisms of action associated with the intake of this polyphenol-rich extract.

研究背景：多酚类化合物（Polyphenols）是植物中天然存在的有机化合物。现有研究表明，摄入此类化合物可降低认知衰退及相关痴呆症的发病风险。葡萄与蓝莓均为富含多酚的食物，其潜在的认知增强效应已受到学界广泛关注。
研究目的：探究标准化且获专利的富含多酚葡萄蓝莓提取物（Memophenol™）补充剂对轻度认知障碍老年人群认知功能的影响。
研究设计：双臂、6个月随访、平行分组、随机双盲安慰剂对照试验。
研究方法：招募143名年龄介于60至80岁的轻度认知障碍志愿者，将其随机分为两组，分别每日两次补充150mg Memophenol™或安慰剂。本研究的结局指标包括计算机化认知任务测试、执行功能行为评定量表（Behavior Rating Inventory of Executive Function, BRIEF-A）、认知失败问卷以及CASP-19量表。
研究结果：与安慰剂组相比，Memophenol™补充剂可显著改善信息处理速度（p=0.020）、视觉空间学习能力（p=0.012）以及BRIEF-A总分（p=0.046）。但在其余评估的认知测试或自评问卷表现上，两组未观察到其他具有统计学意义的组间差异。此外，Memophenol™补充剂耐受性良好，未出现严重不良反应报告。
研究结论：本试验的积极结果表明，为期6个月的Memophenol™补充或可改善轻度认知障碍成人的部分认知功能。后续需开展进一步研究以拓展当前发现，并明确该富含多酚提取物摄入相关的潜在作用机制。