Supplementary Material for: Global scientific trends in continuous renal replacement therapy from 2000 to 2023: A bibliometric and visual analysis

Introduction: Continuous renal replacement therapy (CRRT) is one of the most widely used blood purification and organ support methods in the ICU. However, the development process, the current status, hotspots, and future trends of CRRT remain unclear.
Method: The WoSCC database was used to analyze CRRT research evolution and theme trends. VOSviewer was used to construct co-authorship, co-occurrence, co-citation, and network visualizations. Citespace is used to detect bursts for co-occurrence items. Several important subtopics were reviewed and discussed in more detail.
Results: Global publications increased from 56 in 2000 to 398 in 2023, a 710.71% increase. Blood Purification published the most manuscripts, followed by International Journal of Artificial Organs. The United States, the San Bortolo Hospital, and Bellomo, R were the most productive and impactful institution, country, and author respectively. Based on co-occurrence cluster analysis, five clusters emerged: (1) Clinical applications and management of CRRT; (2) Sepsis and CRRT; (3) CRRT anticoagulant management; (4) CRRT and antibiotic pharmacokinetics and pharmacodynamics; and (5) Comparison of CRRT and intermittent hemodialysis. COVID-19, initiation, ECOMO, cefepime, guidelines, cardiogenic shock, biomarker and outcome were the latest high-frequency keywords or strongest bursts, indicating the emerging frontiers of CRRT.
Conclusions: There has been widespread publication and citation of CRRT research in the past two decades. We provide an overview of current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers.

引言：连续性肾脏替代治疗（Continuous renal replacement therapy, CRRT）是重症监护病房（Intensive Care Unit, ICU）中应用最为广泛的血液净化与器官支持手段之一。然而，目前学界对CRRT的发展历程、研究现状、热点方向及未来趋势仍缺乏清晰认知。
研究方法：本研究采用Web of Science核心合集（Web of Science Core Collection, WoSCC）数据库，分析CRRT领域的研究演进与主题趋势。使用VOSviewer构建作者合作、关键词共现、文献共被引及网络可视化图谱；利用Citespace检测共现项的突发特征。此外，对若干重要子主题进行了更为细致的综述与探讨。
研究结果：全球范围内相关文献发表量从2000年的56篇增长至2023年的398篇，增幅达710.71%。发表文献数量最多的期刊为《Blood Purification》（《血液净化》），其次为《International Journal of Artificial Organs》（《国际人工器官杂志》）。在发文量与影响力方面，美国为最具产出力的国家，圣博托洛医院（San Bortolo Hospital）为最具产出力的机构，Bellomo, R为最具影响力的作者。通过共现聚类分析，本研究共得到5个聚类主题：（1）CRRT的临床应用与管理；（2）脓毒症（Sepsis）与CRRT；（3）CRRT抗凝管理；（4）CRRT与抗生素药代动力学及药效动力学；（5）CRRT与间歇性血液透析（intermittent hemodialysis）的对比分析。COVID-19、启动时机、ECOMO、头孢吡肟（cefepime）、临床指南、心源性休克（cardiogenic shock）、生物标志物（biomarker）与预后（outcome）为最新出现的高频关键词或最强突发特征项，提示了CRRT领域的新兴前沿方向。
结论：近二十年来，CRRT领域的研究文献已得到广泛发表与引用。本研究对该领域的当前趋势、全球合作模式、核心基础知识、研究热点及新兴前沿方向进行了全面综述。