Behavioral functioning: BASC-II (child) in Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women, PH100

BASC-II Child Self-Report of Behavior, summary scores
Study Description
The PHACS Surveillance Monitoring for ART Toxicities (SMARTT) Study was designed to identify potential adverse effects of ARV exposures in infants born to women with HIV infection, and to evaluate associations with ARV combinations and specific ARV drugs in order to help inform treatment guidelines for HIV-infected pregnant women. SMARTT follows two cohorts of HIV- and ART-exposed but uninfected children: the Static and Dynamic cohorts. Domains of interest include birth outcomes, growth, metabolic, cardiac, neurological, neurodevelopmental, behavior, language, and hearing. Biospecimens are available. SMARTT participants include a Static cohort (n=1240) enrolled at age 1-12 years, a Dynamic cohort (n=1016) enrolled during gestation or < 1 week after birth, and a Reference cohort (n=239) of 50-60 children enrolled at each of ages 1, 3, 5, and 9 years.

儿童行为自评量表第二版（BASC-II）行为自评汇总得分
研究概况
PHACS抗逆转录病毒治疗毒性监测（SMARTT）研究旨在识别HIV感染女性所生婴儿暴露于抗逆转录病毒药物（Antiretroviral, ARV）后可能出现的不良反应，并评估其与ARV联合方案及特定ARV药物之间的关联，以期为HIV感染孕妇的治疗指南制定提供参考依据。该研究纳入两队列均暴露于HIV与抗逆转录病毒治疗（Antiretroviral Therapy, ART）但未感染HIV的儿童：静态队列与动态队列。研究关注的领域包括分娩结局、生长发育、代谢指标、心脏功能、神经系统状态、神经发育水平、行为表现、语言能力与听力水平。研究留存有生物样本。SMARTT研究的研究对象包括：静态队列（n=1240），于1~12岁年龄段招募；动态队列（n=1016），于妊娠期或出生后1周内招募；参考队列（n=239），分别在1岁、3岁、5岁及9岁四个年龄段各招募50~60名儿童。