Additional file 2 of The relationships between women’s reproductive factors: a Mendelian randomisation analysis

Additional file 2: Table S1 Relationships where bi-directional MR was performed due to unclear temporal ordering. Table S2 Relationships investigated. Table S3 Replication consortia and studies. Table S4 Genetic correlation results. Table S5 Primary analysis (IVW). Table S6 Negative control results. Table S7 Heterogeneity for primary analysis. Table S8 Additional MR methods in relation to primary analysis. Table S9 Egger intercept test for the primary analysis. Table S10 I-squared statistics. Table S11 MR PRESSO Global test for primary analysis. Table S12 MR PRESSO Outlier correction for primary analysis. Table S13 Steiger results for the primary analysis. Table S14 Steiger: SNPs found to be in the incorrect intended for the primary analysis direction. Table S15 Steiger filtered MR results for the primary analysis. Table S16 Split sample SNPs, R2, F stats and number of overlapping SNPs. Table S17 Split sample GWAS overlapping SNPs between samples. Table S18 IVW UKBB split sample results. Table S19 UKBB meta-analysed split sample results. Table S20 Replication SNPs, R2 and F stats. Table S21 IVW UKBB and replication results. Table S22 MRlap number of SNPs. Table S23 MRlap observed and corrected results. Table S24 MVMR findings adjusted for childhood body size (UK Biobank).

附加文件2：表S1 因时间顺序不明确而开展双向孟德尔随机化（Mendelian Randomization, MR）分析的关联关系。表S2 本研究所考察的关联关系。表S3 复制研究协作组及纳入的研究。表S4 遗传相关分析结果。表S5 主分析（逆方差加权法，Inverse Variance Weighted, IVW）。表S6 阴性对照分析结果。表S7 主分析的异质性检验结果。表S8 适配主分析的补充MR分析方法。表S9 主分析的Egger截距检验结果。表S10 I²统计量结果。表S11 主分析的MR-PRESSO全局检验结果。表S12 主分析的MR-PRESSO离群值校正结果。表S13 主分析的Steiger检验结果。表S14 Steiger检验：主分析中被检出方向与预设不符的单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）。表S15 主分析经Steiger过滤后的MR分析结果。表S16 拆分样本的SNPs、R²、F统计量及重叠SNPs数量。表S17 拆分样本全基因组关联分析中样本间的重叠SNPs。表S18 英国生物银行（UK Biobank, UKBB）拆分样本的IVW分析结果。表S19 英国生物银行拆分样本的荟萃分析结果。表S20 复制分析所用SNPs、R²及F统计量。表S21 英国生物银行IVW分析及复制分析结果。表S22 MRlap分析的SNPs数量。表S23 MRlap分析的观测值与校正值结果。表S24 基于英国生物银行数据、针对儿童期体尺进行校正的多变量孟德尔随机化（Multivariable Mendelian Randomization, MVMR）分析结果。