Stereoselective Synthesis of 2-Dienyl-Substituted Pyrrolidines Using an η⁴-Dienetricarbonyliron Complex as the Stereodirecting Element: Elaboration to the Pyrrolizidine Skeleton

Primary amines react with keto-aldehyde functionality located in the side-chain of an η4-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C−H insertion and radical cyclization strategy, respectively.伯胺可与η⁴-二烯三羰基铁配合物（η⁴-dienetricarbonyliron complex）侧链所含的酮醛官能团发生反应，以优异的非对映选择性得到相应的吡咯烷产物。其中两个吡咯烷产物1i与1k，分别通过1,5-碳氢插入（1,5-C−H insertion）和自由基环化策略，被衍生为吡咯里西啶类化合物。