Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease [bulk RNA-seq]. Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease [bulk RNA-seq]

The PLCG2 variants bidirectionally modulate disease pathology by inducing distinct transcriptional programs that identify microglial subpopulations associated with protective or detrimental phenotypes Overall design: We performed RNAseq using cortex samples from 7.5-month-old 5xFAD, 5xFADM28L, and 5xFADP522R mice

磷脂酶Cγ2（PLCG2）变异体可通过诱导特异性转录程序，这些程序能够识别与保护性或有害表型相关的小胶质细胞亚群，进而双向调控疾病病理进程。实验设计：我们对7.5月龄的5xFAD、5xFADM28L及5xFADP522R小鼠的皮层样本进行了RNA测序（RNAseq）。