Single-cell transcriptome profiling during the in vitro differentiation of mouse ESCs (mESCs) into epiblast-like cells (EpiLCs).
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=341fa08b5ed8be17756a538c13141da4
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资源简介：
We performed single-cell RNA sequencing (RNA-seq) during the in vitro transition of mouse ESCs (mESCs) from a naïve pluripotent state into epiblast-like cells (EpiLCs), a primed pluripotent state. We derived pseudotime expression trajectories to investigate transcript dynamics of key metabolic regulators, with the aim to identify metabolic pathways that potentially impact on early embryonic cell state transitions.
我们在小鼠胚胎干细胞（mESCs）从初始多能状态向始发多能状态的上胚层样细胞（EpiLCs）的体外转化过程中，开展了单细胞RNA测序（RNA-seq）。我们构建了拟时表达轨迹以探究关键代谢调控因子的转录本动态变化，旨在识别可能影响早期胚胎细胞状态转变的代谢通路。
提供机构：
University of Cambridge
创建时间：
2022-02-20
