The relationship between XPD Asp312Asn Polymorphism and esophageal cancer in Chinese population: a meta-analysis

Abstract It has been reported that xeroderma pigmentosum group D (XPD) Asp312Asn is related to esophageal cancer (EC). Nevertheless, in 12 recent years, some researchers have put forward different points of view. Thus, we aimed to investigate the relation between XPD Asp312Asn polymorphism and the risk of EC in Chinese. Related studies were searched in the databases between the beginning to October 2019. An OR with 14 the corresponding 95% CI was carried out to appraise the relevance. There were 8 studies with 2553 esophageal cancer cases and 3091 controls in 15 this meta-analysis. Due to no heterogeneities among the selected studies of all the four genetic models, fxed-effect model was used in each genotype. There was not significant relationship between XPD Asp312Asn polymorphism and EC in overall analyses by pooled ORs and subgroup analyses stratified by geographic area and source of controls. In conclusion, there may be not association between XPD Asp312Asn polymorphism and EC in Chinese populations. Further studies about other ethnic groups are needed to confirm this conclusion.

摘要：已有研究证实，着色性干皮病D组（xeroderma pigmentosum group D, XPD）基因Asp312Asn多态性与食管癌（esophageal cancer, EC）存在关联。然而近12年来，部分研究者对此提出了不同观点。本研究旨在探讨中国人群中XPD基因Asp312Asn多态性与食管癌发病风险的相关性。我们检索了建库伊始至2019年10月的相关数据库文献，采用比值比（OR）及其对应的95%置信区间（95% CI）评估二者的关联强度。本次荟萃分析共纳入8项研究，涉及2553例食管癌患者与3091例对照个体。由于所有四种遗传模型的纳入研究间均无异质性，故各基因型分析均采用固定效应模型。基于合并OR的整体分析，以及按地理区域、对照来源进行的亚组分析均显示，XPD基因Asp312Asn多态性与食管癌发病风险无显著关联。综上，中国人群中XPD基因Asp312Asn多态性与食管癌可能不存在显著关联。后续仍需针对其他种族人群开展相关研究以验证该结论。