Krill oil modulates intestinal inflammation and ameliorates Th2-driven colon injury via the interaction with gut microbiome and histidine metabolism in a porcine model

Anti-inflammatory properties of omega 3 polyunsaturated fatty acids (PUFA) have been exploited in the prevention and management of inflammatory bowel diseases (IBD) with promising results. However, it remains unclear if PUFA play a significant role in the resolution of inflammation and promote mucosal healing. In this study, we attempted to understand the mechanisms through which krill oil (KO), a natural product rich in PUFA and potent antioxidant astaxanthin, modulate the gut microbiome and metabolome using multi-omics based approaches in in vitro and in vivo colitis models.

ω-3多不饱和脂肪酸（omega 3 polyunsaturated fatty acids, PUFA）的抗炎特性已被应用于炎症性肠病（inflammatory bowel diseases, IBD）的预防与管理，且取得了颇具前景的研究成果。然而，目前仍不清楚PUFA是否在炎症消退及促进黏膜愈合中发挥关键作用。本研究借助体外及体内结肠炎模型，采用多组学研究方法，旨在探究富含PUFA与强效抗氧化剂虾青素的天然产物磷虾油（krill oil, KO）调控肠道菌群与代谢组的具体机制。