Serotonin and anxiety-related events

Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms"). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3944 CPTAC Assay Portal]

压力与焦虑症为抑郁症的诱发因素，此类行为受皮质释放因子（CRFR1）和血清素（5-HT2R）受体的调节。相关研究指出，5-羟色胺型2A受体通过蛋白激酶C依赖性和钙/钙调蛋白依赖性机制调节神经元细胞系中环磷酸腺苷的积累（来源：Berg 等《5-羟色胺型2A受体通过蛋白激酶C依赖性和钙/钙调蛋白依赖性机制调节神经元细胞系中环磷酸腺苷的积累》）。该通路上的蛋白质已可通过[CPTAC 测定法门户](https://assays.cancer.gov/available_assays?wp_id=WP3944)进行针对性测定。