Crystallographic projects at Structural Biology Core Facility, JU - bringing the state of art support to the users in need. Continuation.

Structural biology is very informative discipline providing strong support to virtually any biochemistry related project, however in many cases a lack of expertise is a barrier limiting application of structural biology techniques in the most exciting projects. Foundation of Structural Biology Core Facility (SBCF) at Jagiellonian University (JU, Krakow, Poland) was motivated by a need of providing a support of local experts to biochemists who could potentially benefit from detailed knowledge of their proteins of interest. SBCF is based on two pillars - cryo-EM and macromolecular crystallography. The later being conducted with the use of state-of-art beamlines at European synchrotron radiation sources. Since 2019 SBCF assisted in over 55 peer-reviewed publications. With this proposal we'd like to apply for an access to state of the art crystallographic bemlines at ESRF to help our user community to benefit from the brightest and most advanced X-ray sources in Europe.

结构生物学（Structural Biology）是一门信息高度丰富的学科，几乎可为所有生物化学相关研究项目提供强有力的支撑；然而在诸多场景中，专业知识的匮乏仍是制约结构生物学技术应用于极具创新性研究项目的核心障碍。波兰克拉科夫雅盖隆大学（Jagiellonian University, JU）设立结构生物学核心设施（Structural Biology Core Facility, SBCF），其初衷是为生物化学家提供本地专业专家支持，使他们能够从目标蛋白质的详细解析信息中获益。SBCF以两大技术支柱为核心：冷冻电子显微镜（cryo-Electron Microscopy, cryo-EM）与大分子晶体学，其中后者依托欧洲同步辐射光源的顶级光束线开展研究。自2019年以来，SBCF已协助完成超过55篇经同行评议的学术论文。本次申请旨在申请使用欧洲同步辐射装置（European Synchrotron Radiation Facility, ESRF）的顶级晶体学光束线，以助力我们的用户群体得以依托欧洲最先进、最卓越的X射线光源开展相关研究。